Subtypes


Web

  • http://www.drugs.com/mtm/docetaxel.html
  • Docetaxel is a cancer medication that interferes with the growth and spread of cancer cells in the body.
  • http://www.medicines.org.uk/emc/medicine/26747
  • The use of docetaxel should be confined to units specialised in the administration of cytotoxic chemotherapy and it should only be administered under the supervision of a physician qualified in the use of anticancer chemotherapy (see section 6.6)....
  • https://en.wikipedia.org/wiki/Docetaxel
  • Docetaxel is approved by the FDA for treatment of locally advanced or metastatic breast cancer, head and neck cancer, gastric cancer, hormone-refractory prostate cancer and non small-cell lung cancer.[1] Docetaxel can be used as a single agent or in comb...
  • http://www.uwhealth.org/health/topic/multum/taxotere/d04009a1.html
  • You should not receive this medicine if you have ever had a severe allergic reaction to docetaxel or to any medicine that contains polysorbate 80.
  • http://chemocare.com/chemotherapy/drug-info/Taxotere.aspx
  • Taxotere is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.Taxotere is classified as a "plant alkaloid," a "taxane" and an "antimicrotubule agent."
  • http://www.cancer.gov/about-cancer/treatment/drugs/docetaxel/
  • This page contains brief information about docetaxel and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
  • http://www.diagnosia.com/en/drug/taxotere-160-mg8-ml-concentrate-...
  • The name of this medicine is TAXOTERE.Its common name is docetaxel.
  • http://www.nps.org.au/medicines/cancers/antimetabolites-chemother...
  • Taxotere 1 Vial Concentrate solution for infusion is a brand of medicine containing the active ingredient docetaxel.
  • http://www.oncolink.org/treatment/article.cfm?c=2&id=124&aid=446
  • Docetaxel works by disrupting the microtubular network in cells, which is essential for cell division and other normal cellular functions.
  • http://www.drugbank.ca/drugs/DB01248
  • Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer.
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    News

    Efficacy of a docetaxel-5FU-oxaliplatin regimen (TEFOX) in first-line treatment of advanced gastric signet ring cell carcinoma: an AGEO multicentre study
    Nature - Wednesday, September 12, 2018
    Successful Treatment of Hurthle Cell Thyroid Carcinoma with Lung and Liver Metastasis Using Docetaxel and Cisplatin
    Oxford Journals - Wednesday, July 18, 2018
    MHSPC: Increased Survival with Added Docetaxel Confirmed Long-Term
    Medpage Today - Wednesday, April 18, 2018
    Treatment after ADT plus docetaxel
    Nature - Thursday, November 30, 2017
    Novel role of Stat1 in the development of docetaxel resistance in prostate tumor cells
    Nature - Tuesday, November 28, 2017
    Should docetaxel be standard of care for patients with metastatic hormone-sensitive prostate cancer? Pro and contra
    Oxford Journals - Wednesday, November 22, 2017
    Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer
    Nature - Monday, November 20, 2017
    Randomized controlled trial of S-1 versus docetaxel in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy (East Asia S-1 Trial in Lung Cancer)
    Doi - Monday, November 20, 2017
    Docetaxel-Based Chemo Ups Survival in Gastric Cancer
    Medpage Today - Saturday, November 11, 2017
    Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: application to pharmacokinetic studies
    Nature - Friday, November 3, 2017
    Cristal studies CriPec-docetaxel in Phase Ib oncology programme
    Drugdevelopment-Technology.com - Friday, November 3, 2017
    Cetuximab, docetaxel, and cisplatin as first-line treatment in patients with recurrent or metastatic head and neck squamous cell carcinoma: a multicenter, phase II GORTEC study
    Oxford Journals - Tuesday, September 19, 2017
    Ramucirumab plus docetaxel prolongs PFS in advanced urothelial cancers
    Medwirenews - Wednesday, September 13, 2017
    Enhanced antitumor effect on intrapulmonary tumors of docetaxel lung-targeted liposomes in a rabbit model of VX2 orthotopic lung cancer
    Nature - Wednesday, August 30, 2017
    Disease-free and overall survival at 3.5 years for neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide, for women with HER2 negative early breast cancer: ARTemis Trial
    Doi - Tuesday, August 8, 2017
    Combination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1
    Nature - Wednesday, June 14, 2017
    Selumetinib adds no benefit to docetaxel in KRAS-mutant advanced NSCLC
    Medwirenews - Friday, May 19, 2017
    Adding Selumetinib to Docetaxel Doesn't Up PFS in NSCLC
    Physicians Briefing - Thursday, May 11, 2017
    MORE NEWS

    Videos

    Atezolizumab monotherapy vs docetaxel in 2nd and 3rd line NSCLC
         
    Dr Vansteenkiste talks to ecancertv at ECC 2015 about POPLAR, a randomised phase II study comparing atezolizumab and docetaxel as second- and third-line treatment for non-small cell lung cancer (NSCLC). The study findings show that atezolizumab monothe...

    Ramucirumab plus docetaxel extends survival in advanced NSCLC
         
    Visit http://www.ecancer.org for more. Dr Pérol talks to ecancertv at ASCO 2014 about the findings from the REVEL phase III study of patients with stage IV non-small cell lung cancer (NSCLC), which indicate that a combination of a new anti-angiogenesi...

    Evolution of Treatment for Metastatic Castration-Resistant Prostate Cancer
         
    The panelists discuss the evolution of treatment for patients with mCRPC, from the introduction of docetaxel to the advent of newer agents including cabazitaxel. For more from this discussion, visit http://www.onclive.com/peer-exchange/treating-mcrpc...

    SABCS 2011: CLEOPATRA trial, efficacy and safety of pertuzumab, trastuzumab, docetaxel
           
    For more videos from SABCS 2011 and on breast cancer visit ecancer.org/tv At a press conference at the annual ASH meeting 2011, Porf Jose Baselga discusses te CLEOPATRA trial. Background information from the abstract states: pertuzumab (P) is a fu...

    Systemic Therapy for Stage IV Non-Small Cell Lung Cancer ; Cancer.Net
           
    Docetaxel (Docefrez, Taxotere)

    NIH VideoCasting Past Events
           
    al products meet cellular targets: A potential role of IGF-1 receptor in lycopene and docetaxel combination for prostate cancer therapy

    UPMC Physician Resources: Ongoing Clinical Trials
           
    UPCI 12-104: Phase 1B/2 study of vorinostat in combination with gemcitabine and docetaxel in advanced sarcoma.

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    Images

    320px Docetaxel Severe Adverse Effects Graph
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    A woman being treated with docetaxel chemotherapy for breast cancer.
    320px Docetaxel Severe Adverse Effects Graph
    en.wikipedia.org
    320px Docetaxel Adverse Effects Graph
    en.wikipedia.org
    250px Docetaxel 3D
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    250px Docetaxel svg
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    A woman being treated with docetaxel chemotherapy for breast cancer.
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    Docetaxel
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    A woman being treated with docetaxel chemotherapy for breast cancer.
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    en.wikipedia.org
    Docetaxel
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    A woman being treated with docetaxel chemotherapy for breast cancer.
    en.wikipedia.org
    docetaxel fig 3
    drugs.com
    docetaxel fig 2
    docetaxel fig 1
    Docetaxel (anhydrous) is a white to almost-white powder with an empirical formula of C43H53NO14, and a molecular weight of 807.88.
    Kaplan,Meier curves of overall survival for advanced oesophagogastric cancer patients treated with weekly docetaxel along with cisplatin and 5-fluorouracil (wTCF; n,50), or weekly docetaxel with capecitabine (wTX; n,56).
    Kaplan,Meier curves of progression-free survival for advanced oesophagogastric cancer patients treated with weekly docetaxel, plus cisplatin and 5-fluorouracil (wTCF; n,50), or weekly docetaxel with capecitabine (wTX; n,56).
    docetaxel fig 2
    drugs.com
    docetaxel fig 1
    drugs.com
    Docetaxel (anhydrous) is a white to almost-white powder with an empirical formula of C43H53NO14, and a molecular weight of 807.88.
    drugs.com
    Kaplan,Meier curves of overall survival for advanced oesophagogastric cancer patients treated with weekly docetaxel along with cisplatin and 5-fluorouracil (wTCF; n,50), or weekly docetaxel with capecitabine (wTX; n,56).
    nature.com
    Kaplan,Meier curves of progression-free survival for advanced oesophagogastric cancer patients treated with weekly docetaxel, plus cisplatin and 5-fluorouracil (wTCF; n,50), or weekly docetaxel with capecitabine (wTX; n,56).
    nature.com
    Men with hormone-sensitive metastatic prostate cancer who received the chemotherapy drug docetaxel given at the start of standard hormone therapy lived more than a year longer than patients who received hormone therapy alone, according to results from a N
    Giving some men with prostate cancer the intravenous chemotherapy drug, docetaxel, after they had completed radiation and hormone therapy increased how long they lived, according to new study results.
    Influence of docetaxel on transgene expression. (A) HMEC-1 and (B) PC3 cells were infected with 100 and 600 pfu/cell of AdK3 or AdCO1 in the presence of docetaxel corresponding to the ID50.
    Proposed model for the synergistic effect of docetaxel and resveratrol.
    Resveratrol downregulates docetaxel-induced activation of HER-2. (a Kinetics of docetaxel (1 nM)-induced activation of HER-2 in SK-BR-3 cells (0-48 h).
    Men with hormone-sensitive metastatic prostate cancer who received the chemotherapy drug docetaxel given at the start of standard hormone therapy lived more than a year longer than patients who received hormone therapy alone, according to results from a N
    cancer.gov
    Giving some men with prostate cancer the intravenous chemotherapy drug, docetaxel, after they had completed radiation and hormone therapy increased how long they lived, according to new study results.
    cancer.gov
    Influence of docetaxel on transgene expression. (A) HMEC-1 and (B) PC3 cells were infected with 100 and 600 pfu/cell of AdK3 or AdCO1 in the presence of docetaxel corresponding to the ID50.
    nature.com
    Proposed model for the synergistic effect of docetaxel and resveratrol.
    nature.com
    Resveratrol downregulates docetaxel-induced activation of HER-2. (a Kinetics of docetaxel (1 nM)-induced activation of HER-2 in SK-BR-3 cells (0-48 h).
    nature.com
    Resveratrol enhances docetaxel-induced apoptosis in SK-BR-3 cells. (a) Cells were treated with resveratrol and/or docetaxel for 16 h and stained for Annexin V-propidium iodide (PI) posisitivity.
    Patients treated with docetaxel at a dose of 75 mg/m2 experienced no deterioration in performance status and body weight relative to the comparator arms used in these trials.
    Efficacy of Docetaxel in the Treatment of Breast Cancer Patients Previously Treated with an Anthracycline-Containing Regimen.png
    Efficacy of Docetaxel in the Treatment of Breast Cancer Patients Previously Treated with an Alkylating-Containing Regimen.png
    Docetaxel structure.png
    Resveratrol enhances docetaxel-induced apoptosis in SK-BR-3 cells. (a) Cells were treated with resveratrol and/or docetaxel for 16 h and stained for Annexin V-propidium iodide (PI) posisitivity.
    nature.com
    Patients treated with docetaxel at a dose of 75 mg/m2 experienced no deterioration in performance status and body weight relative to the comparator arms used in these trials.
    wikidoc.org
    Efficacy of Docetaxel in the Treatment of Breast Cancer Patients Previously Treated with an Anthracycline-Containing Regimen.png
    wikidoc.org
    Efficacy of Docetaxel in the Treatment of Breast Cancer Patients Previously Treated with an Alkylating-Containing Regimen.png
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    Docetaxel structure.png
    wikidoc.org
    Docetaxel structural formula.jpg
    Docetaxel FDA package label.png
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    Docetaxel 160 mg.png
    Docetaxel structural formula.jpg
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    Docetaxel FDA package label.png
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    Docetaxel 80 mg.png
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    Docetaxel 20mg.png
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    Docetaxel 160 mg.png
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    docetaxel 9
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    TAX320 Survival K-M Curves -TAXOTERE 75 mg/m² vs. Vinorelbine or Ifosfamide Control - Illustration
    TAX317 Survival K-M Curves -TAXOTERE 75 mg/m² vs. Best Supportive Care - Illustration
    docetaxel 9
    rxlist.com
    docetaxel 7
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    TAX320 Survival K-M Curves -TAXOTERE 75 mg/m² vs. Vinorelbine or Ifosfamide Control - Illustration
    rxlist.com
    TAX317 Survival K-M Curves -TAXOTERE 75 mg/m² vs. Best Supportive Care - Illustration
    rxlist.com
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