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ASCO 2010: Phase III clinical trials at ASCO 2010


Paclitaxel News
Novel Anti-tumor Strategy for Breast Cancer: Synergistic Role of Oleuropein with Paclitaxel Therapeutic in MCF-7 Cells
Ingentaconnect - Monday, January 29, 2024
Knockdown of PROM2 Enhances Paclitaxel Sensitivity in Endometrial Cancer Cells by Regulating the AKT/FOXO1 Pathway
Ingentaconnect - Wednesday, November 29, 2023
Safety and Efficacy Analysis of PD-1 Inhibitors in Combination with Gemcitabine Plus Nab-Paclitaxel for Advanced Pancreatic Cancer: A Real-World, Single-Center Study
Dove Press - Monday, November 13, 2023




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Web

  • Paclitaxel medical facts from Drugs.com
  • http://www.drugs.com/mtm/paclitaxel.html
  • Paclitaxel is a cancer medication that interferes with the growth and spread of cancer cells in the body.
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  • Paclitaxel (Taxol, Onxal) Chemotherapy Drug Information
  • http://chemocare.com/chemotherapy/drug-info/Paclitaxel.aspx
  • Paclitaxel is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.Paclitaxel is classified as a "plant alkaloid," a "taxane" and an "antimicrotubule agent."
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  • Paclitaxel - National Cancer Institute
  • http://www.cancer.gov/about-cancer/treatment/drugs/paclitaxel/
  • This page contains brief information about paclitaxel and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
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  • Abraxane Powder for injection ; NPS MedicineWise
  • http://www.nps.org.au/medicines/cancers/antimetabolites-chemother...
  • Abraxane Powder for injection is a brand of medicine containing the active ingredient paclitaxel, nab.
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  • Paclitaxel - Wikipedia, the free encyclopedia
  • https://en.wikipedia.org/wiki/CT-2103
  • Paclitaxel is a drug used to treat ovarian, breast, lung, pancreatic and other cancers. [2] It and docetaxel represent the taxane family of drugs.
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  • FDA Approves Celgene Corporations Abraxane for Lung Cancer
  • http://www.biospace.com/News/fda-approves-celgene-corporations-ab...
  • "The FDA approval of ABRAXANE is exciting for healthcare professionals because it offers an important new treatment option for all types of non-small cell lung cancer patients, in an area that has seen few treatment advancements in recent years." ...
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  • Paclitaxel (Taxol
  • http://www.oncolink.org/treatment/article.cfm?c=2&id=145&aid=430
  • Paclitaxel is a plant alkaloid that was developed from the bark of the Pacific Yew tree.
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  • Paclitaxel (taxol (R)) - Cancer Information
  • http://www.macmillan.org.uk/Cancerinformation/Cancertreatment/Tre...
  • During treatment, you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse.
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  • Data abstraction - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent or refractory ovarian cancer
  • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0082095/
  • In cases of prolonged neutropenia (> 7 days with ANC of < 0.5
  • Abraxane ; myVMC
  • http://www.myvmc.com/drugs/abraxane/
  • It is used to treat adult patients who have been unsuccessfully treated with anthracycline (another medicine used to treat metastatic breast cancer).
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    News

    Novel Anti-tumor Strategy for Breast Cancer: Synergistic Role of Oleuropein with Paclitaxel Therapeutic in MCF-7 Cells
    Ingentaconnect - Monday, January 29, 2024
    Knockdown of PROM2 Enhances Paclitaxel Sensitivity in Endometrial Cancer Cells by Regulating the AKT/FOXO1 Pathway
    Ingentaconnect - Wednesday, November 29, 2023
    Safety and Efficacy Analysis of PD-1 Inhibitors in Combination with Gemcitabine Plus Nab-Paclitaxel for Advanced Pancreatic Cancer: A Real-World, Single-Center Study
    Dove Press - Monday, November 13, 2023
    Successful Treatment of Concurrent Follicular Lymphoma and Triple-Negative Breast Cancer Using Rituximab Plus Nab-Paclitaxel and Cisplatin: A Case Report and Literature Review
    Dove Press - Monday, November 13, 2023
    Pearls & Oy-sters: Case of Atypical Peripheral Nerve Findings Following Paclitaxel for Breast Cancer
    Neurology - Saturday, July 29, 2023
    Intraperitoneal paclitaxel is a safe and effective therapeutic strategy for treating mucinous appendiceal adenocarcinoma
    Aacr Journals - Thursday, July 13, 2023
    Remarkable Clinical Response of ALK-Rearranged/TP53-Mutant Lung Adenocarcinoma with Liver Metastasis to Atezolizumab-Bevacizumab-Carboplatin-Paclitaxel After ALK Inhibitors: A Case Report
    Dove Press - Thursday, June 29, 2023
    Read the article titled, Targeted Nanoparticles That Deliver a Sustained, Specific Release of Paclitaxel to Irradiated Tumors
    Doi - Wednesday, May 24, 2023
    Abraxane Approved for Metastatic Pancreatic Cancer
    Doi - Tuesday, November 15, 2022
    Sustained Supratherapeutic Paclitaxel Delivery Enhances Irreversible Sarcoma Cell Death
    Doi - Monday, August 29, 2022
    Inhibition of mTORC1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma
    Aacr Journals - Friday, July 1, 2022
    Successful Treatment with Short-Term Steroid Against Severe Hepatitis Confirmed by Liver Biopsy in a Patient with Advanced Squamous-Cell Lung Cancer Receiving a Combination of Pembrolizumab, Carboplatin, and Nab-Paclitaxel: A Case Report
    Dove Press - Friday, June 10, 2022
    Paclitaxel Devices Safe in PAD In Medicare Data Beyond 3 Years
    Medpage Today - Friday, May 27, 2022
    GAS6-AXL inhibition by AVB-500 overcomes resistance to paclitaxel in endometrial cancer by decreasing tumor cell glycolysis
    Doi - Friday, May 27, 2022
    Weekly vs Every-3-Week Carboplatin with Weekly Paclitaxel in Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer: A Retrospective Analysis
    Dove Press - Saturday, April 23, 2022
    Correction to: Gemcitabine + Nab-paclitaxel or Gemcitabine alone after FOLFIRINOX failure in patients with metastatic pancreatic adenocarcinoma: a real-world AGEO study
    Nature - Friday, March 18, 2022
    CD147 supports paclitaxel resistance via interacting with RanBP1
    Nature - Saturday, February 12, 2022
    Dosing Schedules of Gemcitabine and nab-Paclitaxel for Older Adults With Metastatic Pancreatic Cancer
    Academic - Tuesday, January 18, 2022
    MORE NEWS

    Videos

    ASCO 2010: Phase III clinical trials at ASCO 2010
         
    Prof Patrick Schöffski - Catholic University Leuven, Belgium Prof Schöffski talks about two phase III trial results presented at ASCO 2010. The first of these demonstrated that the tyrosine kinase inhibitor vandetanib increases progression free survi...
    Combination of pazopanib and paclitaxel safe in urothelial cancer
           
    Prof Sandy Srinivas, (Stanford University Medical Centre, Stanford, USA) talks to ecancertv at ASCO GU 2015 about the results of a phase II study which looked at the use of pazopanib with weekly paclitaxel in refractory urothelial cancer.
    Clifford A. Hudis, MD: Paclitaxel Beats Out Newer Agents in the Treatment of Advanced Breast Cancer
           
    Dr. Cliff Hudis discusses paclitaxel beat two newer chemotherapies—nab-paclitaxel (Abraxane) and ixabepilone (Ixempra)—in the treatment of metastatic breast cancer patients who have not had prior systemic therapies. Paclitaxel fared better in terms of...
    My experience with chemotherapy and its side effects ; MyOncofertility.org ; Fertility Preservation Options
           
    And then the second half"I wasn't as nauseous with the Taxol but my bones ached more.
    Systemic Therapy for Stage IV Non-Small Cell Lung Cancer ; Cancer.Net
           
    The targeted therapy bevacizumab (Avastin) may be added to chemotherapy if a patient is receiving a combination of carboplatin (Paraplatin) and paclitaxel (Taxol).
    Thymoma: Treatment Options ; Cancer.Net
           
    Paclitaxel (Taxol)
    Esophageal Cancer: Treatment Options ; Cancer.Net
           
    It may be given by itself or with paclitaxel (Taxol), a type of chemotherapy.
    ASCO 2010: Phase III clinical trials at ASCO 2010
           
    Prof Patrick Schöffski - Catholic University Leuven, Belgium Prof Schöffski talks about two phase III trial results presented at ASCO 2010. The first of these demonstrated that the tyrosine kinase inhibitor vandetanib increases progression free survi...

    Images

    Grinding Yew Bark for Paclitaxel
    Taxol(Paclitaxel)3D.png
    The bark is peeled and processed to provide paclitaxel.
    220px Tubulin paclitaxel 2HXF
    Paclitaxel, with rings labeled and accepted numbering scheme shown.
    Grinding Yew Bark for Paclitaxel
    cancer.gov    		 Taxol(Paclitaxel)3D.png
    en.wikipedia.org    		 The bark is peeled and processed to provide paclitaxel.
    en.wikipedia.org    		 220px Tubulin paclitaxel 2HXF
    en.wikipedia.org    		 Paclitaxel, with rings labeled and accepted numbering scheme shown.
    en.wikipedia.org
    Undisturbed Pacific yew bark contains paclitaxel and related chemicals.
    Space-filling model of paclitaxel
    Rotated paclitaxel molecule model
    108px Paclitaxel JMol Biol 2001 1045
    Molecular structure of paclitaxel.
    Undisturbed Pacific yew bark contains paclitaxel and related chemicals.
    en.wikipedia.org    		 Space-filling model of paclitaxel
    en.wikipedia.org    		 Rotated paclitaxel molecule model
    en.wikipedia.org    		 108px Paclitaxel JMol Biol 2001 1045
    en.wikipedia.org    		 Molecular structure of paclitaxel.
    en.wikipedia.org
    200px Paclitaxel JMol Biol 2001 1045
    Another representation of paclitaxel biosynthesis.
    Baccatin III (left) Paclitaxel (right)
    NCI-funded research delivers a breakthrough discovery with paclitaxel (Taxol), a cancer drug from the bark of the Pacific yew tree that expands treatment options for patients with breast and ovarian cancers.
    With the discovery of the cancer drug paclitaxel (Taxol), patients with breast and ovarian cancers have hope for better treatment outcomes, increased life expectancy, and improved quality of life.
    200px Paclitaxel JMol Biol 2001 1045
    en.wikipedia.org    		 Another representation of paclitaxel biosynthesis.
    en.wikipedia.org    		 Baccatin III (left) Paclitaxel (right)
    en.wikipedia.org    		 NCI-funded research delivers a breakthrough discovery with paclitaxel (Taxol), a cancer drug from the bark of the Pacific yew tree that expands treatment options for patients with breast and ovarian cancers.
    cancer.gov    		 With the discovery of the cancer drug paclitaxel (Taxol), patients with breast and ovarian cancers have hope for better treatment outcomes, increased life expectancy, and improved quality of life.
    cancer.gov
    Mansukh Wani, Ph.D., (left) and Monroe Wall, Ph.D., (right) discovered paclitaxel, a lifesaving compound from the bark of the Pacific yew tree.
    Adjusted Regimen of Abraxane and Gemzar Less Toxic in Pancreatic Cancer
    Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian…
    You have paclitaxel and carboplatin through a drip into a vein once every 3 weeks.
    paclitaxel 9
    Mansukh Wani, Ph.D., (left) and Monroe Wall, Ph.D., (right) discovered paclitaxel, a lifesaving compound from the bark of the Pacific yew tree.
    cancer.gov    		 Adjusted Regimen of Abraxane and Gemzar Less Toxic in Pancreatic Cancer
    curetoday.com    		 Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian
    health.am    		 You have paclitaxel and carboplatin through a drip into a vein once every 3 weeks.
    cancerresearchuk.org    		 paclitaxel 9
    rxlist.com
    paclitaxel 8
    paclitaxel 7
    paclitaxel 6
    paclitaxel 5
    paclitaxel 4
    paclitaxel 8
    rxlist.com    		 paclitaxel 7
    rxlist.com    		 paclitaxel 6
    rxlist.com    		 paclitaxel 5
    rxlist.com    		 paclitaxel 4
    rxlist.com
    paclitaxel 3
    paclitaxel 2
    abraxane 2
    abraxane 3
    ABRAXANE® (paclitaxel) Structural Formula Illustration
    paclitaxel 3
    rxlist.com    		 paclitaxel 2
    rxlist.com    		 abraxane 2
    rxlist.com    		 abraxane 3
    rxlist.com    		 ABRAXANE® (paclitaxel) Structural Formula Illustration
    rxlist.com
    Grinding Yew Bark for Paclitaxel
    The bark is peeled and processed to provide paclitaxel.
    220px Tubulin paclitaxel 2HXF
    Paclitaxel, with rings labeled and accepted numbering scheme shown.
    Undisturbed Pacific yew bark contains paclitaxel and related chemicals.
    Grinding Yew Bark for Paclitaxel
    cancer.gov    		 The bark is peeled and processed to provide paclitaxel.
    en.wikipedia.org    		 220px Tubulin paclitaxel 2HXF
    en.wikipedia.org    		 Paclitaxel, with rings labeled and accepted numbering scheme shown.
    en.wikipedia.org    		 Undisturbed Pacific yew bark contains paclitaxel and related chemicals.
    en.wikipedia.org
    Space-filling model of paclitaxel
    Rotated paclitaxel molecule model
    108px Paclitaxel JMol Biol 2001 1045
    Molecular structure of paclitaxel.
    200px Paclitaxel JMol Biol 2001 1045
    Space-filling model of paclitaxel
    en.wikipedia.org    		 Rotated paclitaxel molecule model
    en.wikipedia.org    		 108px Paclitaxel JMol Biol 2001 1045
    en.wikipedia.org    		 Molecular structure of paclitaxel.
    en.wikipedia.org    		 200px Paclitaxel JMol Biol 2001 1045
    en.wikipedia.org
    MORE IMAGES

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